Open AccessModern angiotensmconverting enzyme inhibitors m correction of cerebral haemodynamics in hypertension
Author(s) -
М. М. Одинак,
Г.Г. Хубулава,
A. N. Kuznetcov,
I. A. Vosnyuk,
Н. А. Арсенова
Publication year - 2006
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2006-12-4-347-350
Subject(s) - perindopril , medicine , cerebral circulation , transcranial doppler , cerebral blood flow , blood pressure , cardiology , hemodynamics , neurology , psychiatry
The study addresses changes of cerebral circulation during perindopril therapy of hypertension. 33 hypertensive patients were included (males - 15 (45,5%); females - 18 (54,5%). 20 patients (60,6%) received perindopril e 4 mg per day, 13 patients of control group were treated by alternative antihypertensive drugs. Neurology status, cerebral circulation (Sonomed, Spectodem, Russia) were evaluated at baseline and after 6 months of treatment. Results obtained demonstrated that perindopril can improve cerebral circulation independently of blood pressure reduction and has angioprotective effect. In conclusion perindopril seems to be effective treatment of hypertension in patients with impaired cerebral blood flow. Transcranial Doppler can be used as effective tool for monitoring of cerebral circulation in such cases.