Open AccessThe Method of apolipoprotein(a) Gene G/A - 772 Polymorphism Detection and the Study of It’s Role in Coronary Heart Disease in intercoronary Stent Placement
Author(s) -
J. V. Skorobogatova,
А. А. Сошнев
Publication year - 2006
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2006-12-3-273-278
Subject(s) - medicine , restenosis , snp , apolipoprotein b , cardiology , angioplasty , single nucleotide polymorphism , coronary heart disease , stent , cholesterol , gene , genotype , biology , genetics
The present study evaluates plasma lipid profile and inflammatory proteins, including lipoprotein(a) [Lp(a)] and apolipoprotein(a) gene single nucleotide polymorphism (SNP) G/А located 772 b.p. upstream transcription start site, in 80 patients undergoing stenting after coronary angioplasty. A novel method of G/А polymorphism detection is described. Our study is the first one to reveal the role of G/А SNP in regulation of plasma Lp(a) levels. We describe an association of LDL and Lp(a) systems limited only to the group of patients with restenosis after coronary stenting. Plasma apolipoprotein Al level increase after stenting was characteristic of better prognosis. The acute phase proteins are studied in association with clinical and angiographic presentation of coronary heart disease. Our data is relevant both to fundamental studies of atherosclerosis and to clinical practice, and may be used in assessment of coronary heart disease clinical course and selection of treatment options.