Open AccessAntiischemic and antiarrhytmic effects of angiotensin-converting enzyme inhibitor zofenopril in the rat model of acute myocardial ischemia
Author(s) -
E. V. Shlyakhto,
М. М. Галагудза,
Ilia O. Blokhin,
V. A. Tsirlin,
А. В. Сыренский,
Е. И. Егорова,
Е. М. Нифонтов
Publication year - 2006
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2006-12-3-237-242
Subject(s) - captopril , medicine , cardiology , myocardial ischemia , ace inhibitor , ischemia , angiotensin converting enzyme , pharmacology , blood pressure
Angiotensin-converting enzyme (ACE) inhibitors are widely used in heart failure therapy, but little is known about their antiischemic effccts. The primary aim of this study was to investigate antiischemic effectiveness of SH-containing ACE inhibitor zofenopril in rats in comparison to captopril. The results provide an evidence that zofenopril, in contrast to captopril, reduces infarct size when administered intravenously at a dose of 2,5 mg/kg 30 minutes before ischemia. Antiischemic effect of zofenopril may be due to its high affinity to myocardial tissue. Unlike captopril, zofenopril exerted significant antiarrhythmic effect against ischemic ventricular tachyarrhytmias. Antiischemic effect of zofenopril was evident at a relatively high dose only and, therefore, was associated with considerable hypotensive effect.