Open AccessTolerance of Rilmenidine and its combination with amlodipine in hypertensive patients (according to ALTAIR study)
Author(s) -
E. Shlyakhto,
Alexandra Konradi
Publication year - 2006
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2006-12-1-80-84
Subject(s) - amlodipine , discontinuation , rilmenidine , adverse effect , medicine , blood pressure , receptor , agonist
The aim of the study was lo evaluate tolerance of rilmenidine and its combination with amlodipine in ALTAIR study population. The study included 677 patients. 610 (90.4 %) completes it successfully. 126 adverse events have been observed, but only in 4.4 % cases it lead to therapy discontinuation. Adverse events were most frequent on i week visit, later due to excluding of some patients and disappearance of several adverse events its rate. The most frequent adverse effect was dry mouth which was registered in 64 (9.5 %) patients. In conclusion, analysis of ALTAIR data indicates that rilmenidine is well tolerated taking alone оr in combination with amlodipine in patients with mold-to-moderate hypertension. Moreover, rilmenidine therapy is accompanied by improvement of quality of life.