Open AccessThe effectiveness and safety of Tulip in patients with hyperlipidemia
Author(s) -
О. М. Моисеева,
Ye. V. Karelkina
Publication year - 2005
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2005-11-3-201-203
Subject(s) - hyperlipidemia , atorvastatin , medicine , creatinine , alanine aminotransferase , cholesterol , total cholesterol , national cholesterol education program , low density lipoprotein , lipoprotein , drug , alanine transaminase , adverse effect , pharmacology , gastroenterology , endocrinology , obesity , metabolic syndrome , diabetes mellitus
The purpose of the study was to evaluate the hypolipidemic effectiveness and safety of use of Tulip, a novel atorvastatin generic agent, registered by LEK, Slovenia, in Russia. Materials and methods. The open prospective uncontrolled study covered in hyperlipidemic patients aged 57,3±1,2 years. Of the 40 patients included into the present study, 19 (47.5 %) achieved the target level of low-density lipoprotein (LDL) cholesterol just by week 4 of therapy when 10 mg of Tulip was used and 7 (17,5 %) patients did by week 8 when 20 mg of the drug was given. As a whole, 65 % of patients achieved the target level of DLD cholesterol in the Tulip group. By treatment week 8, there were35,6; 44,6; 39,8 and 40,9 % decreases in the serum content of total cholesterol, very low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, respectively. The serum level of LDL cholesterol tended to increase. The pronounced hypolipidemic effect of Tulip was not attended by increases in transaminases (aspartate aminotransferase and alanine aminotranferase) and creatinine phosphokinase. Conclusions. The marked hypolipidemic effect of Tulip, which is comparable with that of the original drug atorvastatin, is unquestionable to he attractable for practical use in Russia due to its inexpensive cost. Tulip has demonstrated to be safe and well tolerated.