Open AccessCalcium antagonists: principals of therapy in the light of evidence based studies data
Author(s) -
Сергей Юрьевич Марцевич
Publication year - 2004
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2004-10-1-43-45
Subject(s) - diltiazem , amlodipine , verapamil , nifedipine , felodipine , calcium , medicine , pharmacology , myocardial infarction , heart failure , cardiology , blood pressure
Calcium antagonists (CA) are the group of drugs the main property of which are the ability to inhibit calcium influx through the so-called slow calcium channels. According to chemical structure, CA are divided into dihydropyridines (nifedipine, amlodipine, felodipine) and nondihydropyridines (verapamil and diltiazem). CA are also divided into first generation agents (conventional tablets) and second generation agents (long acting agents), the last are not only more convenient bat also more safe drugs. The data of large randomised trials confirm that CA have favorable effect on life prognosis during their regular administration to patients with arterial hypertension, this effect of CA is similar to that of other antihypertensive drugs (AHD). However, CA may be superior to other AHD in preventing stroke and inferior to other AHD in preventing myocardial infarction and congestive heart failure.