Open AccessRole of nitric oxide and its metabolites in the regulation of vascular tone in hypertensive disease
Author(s) -
O. M. Moiseyeva,
Л. А. Александрова,
I. V. Yemelyanov,
Y. I. Merkulova,
Татьяна Георгиевна Иванова,
А. А. Жлоба
Publication year - 2003
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2003-9-6-202-204
Subject(s) - nitric oxide , vasodilation , reactive hyperemia , lipid peroxidation , medicine , superoxide dismutase , chemistry , endocrinology , oxidative stress
The effects of nitric oxide and its metabolites on vascular tone were studied in patients with hypertensive disease (HD) during isometric exercise and reactive hyperemia tests. During the static loading tests, blood pressure increases were followed by the development of vasospastic reactions, by the higher activity of the sympathetic part of the autonomic nervous system, by a reduction in parasympathetic effects, by a decrease in the activity of superoxide dismutase and in the concentrations of nitrites/nitrates in the plasma, by the activation of lipid peroxidation, and by an increase in the levels of S-nitrosothiols. The reactive hyperemia test showed a higher production of nitric oxide and developed vasodilator reactions. The activation of lipid peroxidation is common to these stress tests. However, the formation of peroxynitrites and S-nitrosothiols aggravates nitric oxide deficiency and potentiates the development of vasoconstrictive reactions in patients with HD under decreased SOD-like activity.