Open AccessCerebrovascular effects of antihypertensive therapy in perimenopausal women
Author(s) -
A. V. Kharakhashyan,
V. P. Terentyev,
Н. И. Волкова,
B. Sokolov
Publication year - 2003
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2003-9-5-177-181
Subject(s) - medicine , lisinopril , metoprolol , cerebral blood flow , hemodynamics , cardiology , blood flow , blood pressure , cerebral arteries , anesthesia , angiotensin converting enzyme
Fifty-six peri- and postmenopausal women with arterial hypertension (AH) who had no history of cerebrovascular disorders were examined. Cerebral blood flow was studied by Doppler ultrasound study of extra- and intracranial arteries. The patients were divided into 2 groups: Group 1 received lisinopril and Group 2 had metoprolol. The studies performed before therapy, at the peak of drug tests, and 1 month after the initiation of therapy. In patients with first- and second-degree AH, cerebral hemodynamic disorders were found to occur at the extra- and intracranial level, which appeared as changes in the velocity characteristics of blood flow and in the indices characterizing cerebrovascular resistance. In addition to blood pressure lowering, lisinopril therapy for AH brought about changes in cerebral blood flow in the extra- and intracranial arteries. The most important changes appeared as a normalized intracranial arterial responsiveness and a diminished peripheral vascular resistance. Metoprolol therapy caused a reduction in the velocity of blood flow, without substantially changing the responsiveness and resistance of cerebral vessels.