Open AccessComparative characteristics of the level of highly sensitive C-reactive protein in patients with systemic lupus erythematosus and rheumatoid arthritis
Author(s) -
Ю. Р. Ахвердян,
Б. В. Заводовский,
Ю. В. Полякова,
Л. Е. Сивордова,
E. Papichev
Publication year - 2021
Publication title -
sibirskij naučnyj medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2410-2520
pISSN - 2410-2512
DOI - 10.18699/ssmj20210409
Subject(s) - medicine , microalbuminuria , rheumatoid arthritis , anti nuclear antibody , rheumatoid factor , c reactive protein , gastroenterology , lupus erythematosus , acute phase protein , arthritis , immunology , urine , antibody , autoantibody , inflammation , disease
The aim of this work was to study the dependence of the concentration of C-reactive protein in the blood of patients on the severity of systemic lupus erythematosus (SLE). Material and methods . We examined 26 patients with SLE, the comparison group consisted of patients with rheumatoid arthritis (RA) ( n = 88). Results . The hsCRP level was significantly higher in patients with a high degree of activity than in patients with minimal and moderate SLE activity ( F = 4.409, p = 0.023). In addition, in patients with SLE, a significant direct correlation was found between hsCRP and ESR values ( r = 0.409, p = 0.047), antinuclear factor ( r = 0.389, p = 0.021), antibodies to double-stranded DNA ( r = 0.226, p = 0.033), leukocytes in urine ( r = 0.571, p = 0.002), microalbuminuria ( r = 0.727, p = 0.017) AsAT ( r = 0.428, p = 0.046), and inverse correlation – with the value of blood leukocytes ( r = –0.662, p < 0.001). Conclusion . It was found that an increase in the levels of hsCRP in the sera of SLE patients is accompanied by an increase in the degree of disease activity, which indicates a direct correlation between the level of hsCRP and SLE activity. Consequently, the concentration of hsCRP reflects the acute phase response and the intensity of the inflammatory process in SLE.