Progress in Alzheimer's Disease Research Based on SIRT1 | Zendy

Wenhui Zhao | Zendy; Jin Qiu | Zendy; Bo Lin | Zendy; Xinshu Zhu | Zendy

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Progress in Alzheimer's Disease Research Based on SIRT1

Author(s) -

Wenhui Zhao,

Jin Qiu,

Bo Lin,

Xinshu Zhu

Publication year - 2019

Publication title -

advances in higher education

Language(s) - English

Resource type - Journals

ISSN - 2424-8428

DOI - 10.18686/ahe.v3i2.1445

Subject(s) - disease , mechanism (biology) , oxidative stress , alzheimer's disease , neuroscience , central nervous system , nervous system , apoptosis , biology , medicine , genetics , endocrinology , philosophy , epistemology

SIRT1 belongs to the family of Sirtuins deacetylase in mammals, which is mainly responsible for regulating the anti-infection, anti-apoptosis and anti-oxidative stress ability of cells. When organisms show degenerative changes in the nervous system, the expression level of SIRT1 will be up-regulated in order to play a protective role in the nervous system. In order to clarify the interaction between SIRT1 and Alzheimer's disease, this paper aims to provide scientific theoretical basis for the treatment of Alzheimer's disease by analyzing the regulation mechanism of SIRT1.

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