Open AccessProgress in Alzheimer's Disease Research Based on SIRT1
Author(s) -
Wenhui Zhao,
Jin Qiu,
Bo Lin,
Xiwen Zhu
Publication year - 2019
Publication title -
advances in higher education
Language(s) - English
Resource type - Journals
ISSN - 2424-8428
DOI - 10.18686/ahe.v3i2.1445
Subject(s) - disease , mechanism (biology) , oxidative stress , alzheimer's disease , neuroscience , central nervous system , nervous system , apoptosis , biology , medicine , genetics , endocrinology , philosophy , epistemology
SIRT1 belongs to the family of Sirtuins deacetylase in mammals, which is mainly responsible for regulating the anti-infection, anti-apoptosis and anti-oxidative stress ability of cells. When organisms show degenerative changes in the nervous system, the expression level of SIRT1 will be up-regulated in order to play a protective role in the nervous system. In order to clarify the interaction between SIRT1 and Alzheimer's disease, this paper aims to provide scientific theoretical basis for the treatment of Alzheimer's disease by analyzing the regulation mechanism of SIRT1.