Open AccessAdvances in the Relationship between Tau Protein and Morphine De-pendence in Cognitive Dysfunction
Author(s) -
Qing Ji,
Xin Li
Publication year - 2021
Publication title -
advanced emergency medicine
Language(s) - English
Resource type - Journals
ISSN - 2315-456X
DOI - 10.18686/aem.v9i4.178
Subject(s) - morphine , tau protein , hyperphosphorylation , oxidative stress , neuroscience , hippocampal formation , cognition , opioid , addiction , hippocampus , psychology , disease , medicine , pharmacology , biology , alzheimer's disease , microbiology and biotechnology , phosphorylation , receptor
Morphine is an opioid drug. Long-term use can cause morphine dependence or addiction, and there are cognitive dysfunction such as abnormal mental behavior, decline in learning and memory, and decline in executive ability. The occurrence of this disease is related to many factors, such as oxidative stress, hippocampal neuronal injury, mitochondrial function injury, etc. Tau protein is a microtubule-associated protein involved in nervous system development. Studies have found that hyperphosphorylation of tau proteins can cause apoptosis of hippocampal neurons [1] , and tau proteins can cause oxidative stress [2] . Therefore, tau proteins play an important role in the pathogenesis of cognitive disorders. The relationship between morphine dependence and cognitive dysfunction is now reviewed.