Open AccessCellular and Molecular Mechanisms of Hepatic Fibrosis
Author(s) -
Minling Cao,
Xiaoling Chi,
Junmin Jiang,
Guangjun Tian
Publication year - 2015
Publication title -
advanced emergency medicine
Language(s) - English
Resource type - Journals
ISSN - 2315-456X
DOI - 10.18686/aem.v4i3.4
Subject(s) - hepatic stellate cell , hepatic fibrosis , extracellular matrix , fibrosis , liver fibrosis , chemistry , microbiology and biotechnology , mechanism (biology) , cancer research , pathology , medicine , biology , philosophy , epistemology
The occurrence of hepatic fibrosis is a multi-factor involved process. The key is the activation of hepatic stellate cells (HSC). Synthesis of extracellular matrix in the liver cells increases while degradation decreases. This paper reviews the tissue factors and the mechanism closely related to the forming of hepatic fibrosis.