Open AccessExhaustion and senescence of CD4 and CD8 T cells that express co-stimulatory molecules CD27 and CD28 in subjects that acquired HIV by drug use or by sexual route
Author(s) -
Leontina Bănică,
Ovidiu Vlaicu,
Raluca Jipa,
Adrian Abagiu,
Ionelia Nicolae,
Emil Neaga,
Dan Oțelea,
Simona Paraschiv
Publication year - 2021
Publication title -
germs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 12
ISSN - 2248-2997
DOI - 10.18683/germs.2021.1242
Subject(s) - cd28 , cd38 , cd8 , immune system , cytotoxic t cell , immunology , t cell , immunosenescence , flow cytometry , senescence , biology , virology , microbiology and biotechnology , in vitro , stem cell , biochemistry , cd34
The human immunodeficiency virus (HIV) infection leads to immune activation, senescence and exhaustion of T cells. Co-stimulatory molecules play important roles in controlling these processes. The CD28 signaling triggers efficient T cell activation, while CD27 provides survival signals to CD28- T cells. Loss of these molecules was associated with senescent phenotype and resistance to checkpoint inhibitors.Romania has faced an HIV outbreak among people who inject drugs (PWID), most of them chronically infected with hepatitis C virus (HCV). HIV/HCV co-infection was associated with increased immune activation and rapid disease progression.