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Helicobacter pylori  has been associated with peptic ulcer and gastric carcinoma. This study aimed to find the seroprevalence of  H. pylori  infection in some male students of Jazan University, Saudi Arabia. Twenty students were enrolled in the study ( n  = 20). Informed consent was obtained from the students. About 2 ml blood was collected intravenously in Improvacuter® evacuated blood collection tubes. The blood was allowed to clot at room temperature. The serum was collected and stored at –20°C for further use. The separated serum was used to detect IgG and IgM antibodies by Enzyme Linked Immunosorbent Assay (ELISA) against  H. pylori  for the in vitro diagnosis. A total of 11 (55.00%) students tested positive for IgG antibodies against  H. pylori  indicating previous infection. All the samples tested negative for IgM antibodies against  H. pylori  indicating no active infection. The seroprevalance of IgG antibodies against  H. pylori  was found to be very high in some male university students and is a cause of concern regarding their health. Obesity ( p  &lt; 0.05; Value statistically significant), stress and bad eating habits, eating out, drinking carbonated beverages, and eating spicy food were some of the factors found to be associated with IgG seropositive students. The students were counseled and were instructed to undergo a confirmatory test and get medical intervention. Further large-scale studies need to be performed to plan action against this disease causing organism and to improve the health of students.

Preliminary Serological Study of Helicobacter pylori Infection in Some University Students