Effect of Low-Molecular Fraction of Fish Peptide Albutrisan-NR on In Vitro Neurogenesis | Zendy

Novikova O Yu | Zendy

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Effect of Low-Molecular Fraction of Fish Peptide Albutrisan-NR on In Vitro Neurogenesis

Author(s) -

Novikova O Yu

Publication year - 2020

Publication title -

recent advances in biology and medicine

Language(s) - English

Resource type - Journals

ISSN - 2378-654X

DOI - 10.18639/rabm.2020.1101035

Subject(s) - dermal papillae , neurogenesis , in vitro , hydrolysate , biology , major duodenal papilla , microbiology and biotechnology , fish <actinopterygii> , chemistry , anatomy , biochemistry , fishery , hair follicle , hydrolysis

The effect of the Albutrisan-NR substrate on the differentiation of the primary brain culture of aging rats and on the culture of the rabbit vibrissa dermal papilla was studied. The substance is a hydrolysate of fish tissue with a molecular weight of up to 5 kDa. It was found that adding 2% of the substance to the culture medium stimulates the growth and differentiation processes in rat brain cells. The possibility of using the substance as a growth factor for 3D cultivation of pluripotent dermal papilla cells and maintaining an uncommitted state was demonstrated. The use of Albutrisan-NR as a trophic factor in neuronal induction of dermal papilla cells was also shown.

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