Open AccessGenetic Epidemiology Studies on Unusual Genetic Morphophenotypes in a Settled Community from South India
Author(s) -
Avinash M. Veerappa,
Archana Suryanarayana,
Latha Shivalingaiaha,
Madhumala K. Sadanandappa,
Shivaprasad H. Sathyanarayana,
Swarna Mathre
Publication year - 2015
Publication title -
recent advances in biology and medicine
Language(s) - English
Resource type - Journals
ISSN - 2378-654X
DOI - 10.18639/rabm.2014.01.59897
Subject(s) - consanguinity , inbreeding , genetics , biology , genetic epidemiology , population , inheritance (genetic algorithm) , genetic analysis , major gene , gene , evolutionary biology , medicine , environmental health
Genetic disorders in a population can be caused in many ways and these genetic disorders are heritable, and are passed down the generations. These disorders are complex, multifactorial, or polygenic, and are associated with the effects of multiple genes in combination with lifestyles and environmental factors. Familial aggregation approach and segregation approach was used in this study to identify the prevalent genetic conditions and their inheritance patterns. Here, we report a population which had a very high number of unusual genetic morphophenotypes. We observed that these unusual morphophenotypes in this population are a result of an interaction between “inbreeding, consanguinity and accumulating mutations”. Statistical analysis revealed that individuals in this population carry more than 20 deleterious recessive genes based on Slatis method of calculating abnormal autosomal recessive genes in individuals.