Open AccessHuman cytomegalovirus may promote tumour progression by upregulating arginase-2
Author(s) -
Helena Costa,
Xinling Xu,
Gitta Overbeek,
Suhas Vasaikar,
C. Pawan K. Patro,
Ourania N. Kostopoulou,
Masany Jung,
Gowhar Shafi,
Sharan Ananthaseshan,
Giorgos Tsipras,
Belghis Davoudi,
AbdulAleem Mohammad,
Hoyin Lam,
Klas Strååt,
Vanessa Wilhelmi,
Mei Shang,
Jesper Tegnér,
Joo Chuan Tong,
Kum Thong Wong,
Cecilia SöderbergNauclér,
Koon-Chu Yaiw
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.9722
Subject(s) - arginase , medicine , downregulation and upregulation , immunology , human cytomegalovirus , cytomegalovirus , cancer research , virology , biology , herpesviridae , human immunodeficiency virus (hiv) , viral disease , virus , gene , arginine , genetics , amino acid
Both arginase (ARG2) and human cytomegalovirus (HCMV) have been implicated in tumorigenesis. However, the role of ARG2 in the pathogenesis of glioblastoma (GBM) and the HCMV effects on ARG2 are unknown. We hypothesize that HCMV may contribute to tumorigenesis by increasing ARG2 expression.