Open AccessHDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer
Author(s) -
Anqi Li,
Zebing Liu,
Ming Li,
Shuling Zhou,
Yan Xu,
Yaoxing Xiao,
Wentao Yang
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.9274
Subject(s) - histone deacetylase 5 , bortezomib , gene knockdown , cancer research , histone deacetylase , biology , medicine , apoptosis , immunology , histone , multiple myeloma , biochemistry , gene
Histone deacetylase 5 (HDAC5) is an important protein in neural and cardiac diseases and a potential drug target. However, little is known regarding the specific role of HDAC5 in breast cancer (BC). We aimed to evaluate HDAC5 expression in human breast tumors and to determine the effects of the inhibition of HDAC5 expression in BC cells.