Open AccessJWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients
Author(s) -
Ji Qian,
Weiyou Zhu,
KeMing Wang,
Lin Ma,
Jin Xu,
Tongpeng Xu,
Oluf Dimitri Røe,
Aiping Li,
Jianwei Zhou,
Yongqian Shu
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.9211
Subject(s) - cytoskeleton , medicine , cancer research , cell , oncology , biology , genetics
JWA, a microtubule-associated protein (MAP) involved in apoptosis, has been identified as a suppressor of metastasis, and it affects cell migration in melanoma and its downregulation in tumor is an idependent negative prognostic factor in resectable gastric cancer. HER2 overexpression has been observed in gastric cancer (GC) cells and implicated in the metastatic phenotype. However, the biological role of JWA in migration and its clinical value in HER2-positive GC remain elusive.