Open AccessUbiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
Author(s) -
Kee-Joe Lim,
JongHo Choi,
Jung Hyun Park,
Hyeon-Ju Cho,
Jang-Joon Park,
Eung-Ji Lee,
Lan Li,
Yong Kee Choi,
KwangHyun Baek
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.8976
Subject(s) - deubiquitinating enzyme , adipogenesis , chemistry , retinoic acid , cancer research , ubiquitin , medicine , biochemistry , gene
Deubiquitination via deubiquitinating enzymes (DUBs) has been emerged as one of the important post-translational modifications, resulting in the regulation of numerous target proteins. In this study, we screened new protein biomarkers for adipogenesis, and related studies showed that ubiquitin specific protease 19 (USP19) as a DUB is gradually decreased during adipogenesis and it regulates coronin 2A (CORO2A) as one of the components for the nuclear receptor co-repressor (NCoR) complex in some studies. The regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis.