Open AccessSerum miR-125b is a non-invasive predictive biomarker of the pre-operative chemoradiotherapy responsiveness in patients with rectal adenocarcinoma
Author(s) -
Edoardo D’Angelo,
Matteo Fassan,
Isacco Maretto,
Carlo Za,
Maura Digito,
Massimo Rugge,
Donato Nitti,
Marco Agostini
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.8725
Subject(s) - medicine , colorectal cancer , chemoradiotherapy , oncology , cancer
Therapeutic management of Locally Advanced Rectal Cancer (LARC) involves pre-operative chemoradiotherapy (pCRT) followed by surgery. However, after pCRT the complete pathological response is approximately 20%, whereas in 20 to 40% of patients the response is poor or absent.