Open AccessGABRA3 promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases
Author(s) -
Liping Liu,
Chenglin Yang,
Jianfei Shen,
Liyan Huang,
Lin Wang,
Hailing Tang,
Wenhua Liang,
Wenlong Shao,
Haibo Zhang,
Jianxing He
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.8700
Subject(s) - metastasis , medicine , lung cancer , adenocarcinoma , downregulation and upregulation , cancer research , cancer , oncology , biology , biochemistry , gene
Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABRA3 is reportedly upregulated in lung cancer. Herein, we show that high GABRA3 protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasis status and poor patient survival. In addition, GABRA3 induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, which enhanced lymphatic metastasis by lung adenocarcinoma both in vitro and in vivo. These results indicate that GABRA3 promotes lymph node metastasis and may thus be an effective therapeutic target for anticancer treatment.