Open AccessAssociation of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies
Author(s) -
Yong Gan,
Jiang Wu,
Shengchao Zhang,
Liqing Li,
Shiyi Cao,
Naomie Mkandawire,
Kun Ji,
Chulani Herath,
Chao Gao,
Hong Xu,
Yanfeng Zhou,
Xingyue Song,
Shanquan Chen,
Yawen Chen,
Tingting Yang,
Jing Li,
Yan Qiao,
Sujuan Hu,
Xiaoxv Yin,
Zuxun Lu
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.8627
Subject(s) - medicine , colorectal cancer , prospective cohort study , meta analysis , cohort study , relative risk , cancer , oncology , cohort , random effects model , confidence interval
A meta-analysis was performed to assess the association of coffee consumption with colorectal cancer and to investigate the shape of the association. Relevant prospective cohort studies were identified by a comprehensive search of the PubMed, Embase and Web of Science databases from their inception through August 2015. Either a random-effects model or fixed-effects model was used to compute the pooled risk estimates when appropriate. Linear and nonlinear dose-response meta-analyses were also performed. Nineteen prospective cohort studies involving 2,046,575 participants and 22,629 patients with colorectal cancer were included. The risk of colon cancer was decreased by 7% for every 4 cups per day of coffee (RR=0.93, 95%CI, 0.88-0.99; P=0.199). There was a threshold approximately five cups of coffee per day, and the inverse association for colorectal cancer appeared to be stronger at a higher range of intake. However, a nonlinear association of rectal cancer with coffee consumption was not observed (P for nonlinearity = 0.214). In conclusion, coffee consumption is significantly associated with a decreased risk of colorectal cancer at ≥ 5 cups per day of coffee consumption. The findings support the recommendations of including coffee as a healthy beverage for the prevention of colorectal cancer.