Open AccessIntraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17
Author(s) -
Quirijn R.J.G. Tummers,
Charlotte E.S. Hoogstins,
Katja N. Gaarenstroom,
Cor D. de Kroon,
Mariëtte I.E. van Poelgeest,
Jaap Vuyk,
Tjalling Bosse,
Vincent T.H.B.M. Smit,
Cornelis J.H. van de Velde,
Adam F. Cohen,
Philip S. Low,
Jacobus Burggraaf,
Alexander L. Vahrmeijer
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.8282
Subject(s) - medicine , breast cancer , ovarian cancer , folate receptor , cancer , gynecology , oncology , cancer cell
Intraoperative fluorescence imaging of the folate-receptor alpha (FRα) could support completeness of resection in cancer surgery. Feasibility of EC17, a FRα-targeting agent that fluoresces at 500nm, was demonstrated in a limited series of ovarian cancer patients. Our objective was to evaluate EC17 in a larger group of ovarian cancer patients. In addition, we assessed the feasibility of EC17 in patients with breast cancer.