Open AccessToll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett's esophagus, dysplasia and adenocarcinoma
Author(s) -
Heikki Huhta,
Olli Helminen,
Petri Lehenkari,
Juha Saarnio,
Tuomo J. Karttunen,
Joonas H. Kauppila
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.8151
Subject(s) - medicine , esophagus , dysplasia , esophageal adenocarcinoma , adenocarcinoma , barrett's esophagus , receptor , epithelium , pathology , esophageal disease , cancer research , gastroenterology , cancer
Toll-like receptors (TLRs) recognize microbial and endogenous ligands and have already shown to play a role in esophageal cancer. In this study, we evaluated especially TLRs that sense bacterial cell wall components in Barrett's esophagus, dysplasia and esophageal adenocarcinoma.