Open AccessOncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal sarcomas
Author(s) -
Doris Helbig,
Michaela A. Ihle,
Katharina Pütz,
Iliana TantchevaPóor,
Cornelia Mauch,
Reinhard Büttner,
Alexander Quaas
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.7845
Subject(s) - hras , cdkn2a , cancer research , atypical fibroxanthoma , carcinogenesis , immunohistochemistry , oncogene , neuroblastoma ras viral oncogene homolog , pathology , biology , amplicon , kras , mutation , cancer , medicine , gene , cell cycle , genetics , polymerase chain reaction
Until now, almost nothing is known about the tumorigenesis of atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Our hypothesis is that AFX is the non-infiltrating precursor lesion of PDS.