Open AccessIntratumoral KIT mutational heterogeneity and recurrent KIT/ PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal stromal tumors
Author(s) -
Jing Gao,
Jian Li,
Yanyan Li,
Zhongwu Li,
Jifang Gong,
Jian Wu,
Na Liu,
Bin Dong,
Changsong Qi,
Jie Li,
Lin Shen
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.7148
Subject(s) - pdgfra , proto oncogene proteins c kit , stromal cell , gist , cancer research , medicine , biology , mutation , pathology , genetics , gene , stem cell , haematopoiesis , stem cell factor
Gastrointestinal stromal tumors (GISTs) with no mutations in exons 9, 11, 13, and 17 of the KIT gene and exons 12, and 18 of the PDGFRA gene were defined as KIT/PDGFRA wild-type and they accounted for ~15-20% of GISTs. However, some KIT/PDGFRA wild-type GISTs with KIT mutations in other exons were occasionally reported. We therefore assessed GISTs to understand the whole genomic genotypes of KIT or PDGFRA genes in KIT/PDGFRA wild-type GISTs.