Open AccessTargeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion
Author(s) -
Claire Henry,
Estelle Llamosas,
Alexandra Maria Knipprath-Mészáros,
Andreas Schoetzau,
Ellen C. Obermann,
Maya Fuenfschilling,
Rosemarie Caduff,
Daniel Fink,
Neville F. Hacker,
Robyn L. Ward,
Viola HeinzelmannSchwarz,
Caroline Ford
Publication year - 2015
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.5643
Subject(s) - epithelial ovarian cancer , cancer research , receptor , ovarian cancer , cell migration , medicine , biology , cell , cancer , microbiology and biotechnology , genetics
In recent years, the Wnt signalling pathway has been implicated in epithelial ovarian cancer and its members have potential as diagnostic, prognostic and therapeutic targets. Here we investigated the role of two Wnt receptor tyrosine kinases (RTKs), ROR1 and ROR2, and their putative ligand, Wnt5a, in ovarian cancer.