Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis | Zendy

Letícia Ferro Leal | Zendy; Ana Carolina Bueno | Zendy; Débora Cristiane Gomes | Zendy; Rafael Haikal Abduch | Zendy; Margaret de Castro | Zendy; Sonir Roberto Rauber Antonini | Zendy

Open Access

Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis

Author(s) -

Letícia Ferro Leal,

Ana Carolina Bueno,

Débora Cristiane Gomes,

Rafael Haikal Abduch,

Margaret de Castro,

Sonir Roberto Rauber Antonini

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.5513

Subject(s) - wnt signaling pathway , apoptosis , hela , western blot , cell growth , catenin , medicine , viability assay , annexin , cell culture , cancer research , biology , signal transduction , gene , genetics

To date, there is no effective therapy for patients with advanced/metastatic adrenocortical cancer (ACC). The activation of the Wnt/beta-catenin signaling is frequent in ACC and this pathway is a promising therapeutic target.

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