Open AccessInhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis
Author(s) -
Letícia Ferro Leal,
Ana Carolina Bueno,
Débora Cristiane Gomes,
Rafael Haikal Abduch,
Margaret de Castro,
Sonir Roberto Rauber Antonini
Publication year - 2015
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.5513
Subject(s) - wnt signaling pathway , apoptosis , hela , western blot , cell growth , medicine , catenin , annexin , viability assay , cell culture , cancer research , chemistry , biology , signal transduction , gene , genetics , biochemistry
To date, there is no effective therapy for patients with advanced/metastatic adrenocortical cancer (ACC). The activation of the Wnt/beta-catenin signaling is frequent in ACC and this pathway is a promising therapeutic target.