Open AccessCorrelation of MET gene amplification and TP53 mutation with PD-L1 expression in non-small cell lung cancer
Author(s) -
Mäher Albitar,
Sucha Sudarsanam,
Wanlong Ma,
Shanqun Jiang,
Wayne Chen,
Vincent Funari,
Forrest Blocker,
Sally Agersborg
Publication year - 2018
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.24455
Subject(s) - mutation , lung cancer , cancer research , gene , correlation , gene expression , cancer , medicine , biology , microbiology and biotechnology , genetics , oncology , geometry , mathematics
The role of MET amplification in lung cancer, particularly in relation to checkpoint inhibition and EGFR WT, has not been fully explored. In this study, we correlated PD-L1 expression with MET amplification and EGFR , KRAS , or TP53 mutation in primary lung cancer.