New therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles | Zendy

Takahiro Nakagomi | Zendy; Taichiro Goto | Zendy; Yosuke Hirotsu | Zendy; Daichi Shikata | Zendy; Yujiro Yokoyama | Zendy; Rumi Higuchi | Zendy; Kenji Amemiya | Zendy; Kenichiro Okimoto | Zendy; Toshio Oyama | Zendy; Hitoshi Mochizuki | Zendy; Masao Omata | Zendy

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New therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles

Author(s) -

Takahiro Nakagomi,

Taichiro Goto,

Yosuke Hirotsu,

Daichi Shikata,

Yujiro Yokoyama,

Rumi Higuchi,

Kenji Amemiya,

Kenichiro Okimoto,

Toshio Oyama,

Hitoshi Mochizuki,

Masao Omata

Publication year - 2018

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.24365

Subject(s) - sarcomatoid carcinoma , lung cancer , biology , cancer , microdissection , pathology , survival analysis , carcinoma , oncology , cancer research , medicine , genetics , gene

Pulmonary sarcomatoid carcinomas are rare and generally aggressive tumors composed of carcinomatous and sarcomatous components; however, the evolution of sarcomatoid cancer has not been elucidated. Here, we aimed to evaluate the mutational profiles and phylogeny of sarcomatoid carcinomas using next generation sequencing and in-silico analysis to facilitate the development of novel therapies.

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