Open AccessNew therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles
Author(s) -
Takahiro Nakagomi,
Taichiro Goto,
Yosuke Hirotsu,
Daichi Shikata,
Yujiro Yokoyama,
Rumi Higuchi,
Kenji Amemiya,
Kenichiro Okimoto,
Toshio Oyama,
Hitoshi Mochizuki,
Masao Omata
Publication year - 2018
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.24365
Subject(s) - sarcomatoid carcinoma , lung cancer , biology , cancer , microdissection , pathology , survival analysis , carcinoma , oncology , cancer research , medicine , genetics , gene
Pulmonary sarcomatoid carcinomas are rare and generally aggressive tumors composed of carcinomatous and sarcomatous components; however, the evolution of sarcomatoid cancer has not been elucidated. Here, we aimed to evaluate the mutational profiles and phylogeny of sarcomatoid carcinomas using next generation sequencing and in-silico analysis to facilitate the development of novel therapies.