Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population | Zendy

Shijia Wang | Zendy; Yue Zhang | Zendy; Min Chen | Zendy; Yong Wang | Zendy; Yifei Feng | Zendy; Ziwei Xu | Zendy; Dongsheng Zhang | Zendy; Yueming Sun | Zendy; Zan Fu | Zendy

Open Access

Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population

Author(s) -

Shijia Wang,

Yue Zhang,

Min Chen,

Yong Wang,

Yifei Feng,

Ziwei Xu,

Dongsheng Zhang,

Yueming Sun,

Zan Fu

Publication year - 2018

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.24299

Subject(s) - chek2 , chek1 , single nucleotide polymorphism , medicine , colorectal cancer , population , cancer , genetics , oncology , gene , biology , genotype , environmental health , mutation , germline mutation , cell cycle , cell cycle checkpoint

The ATR-CHEK1 and ATM-CHEK2 pathway have been confirmed to be related with the DNA damage response (DDR). Many studies have reported that genetic variants in ATR/CHEK1 and ATM/CHEK2 are associated with cancer risk. However, the association between genetic variants in ATR-CHEK1, ATM-CHEK2 pathway genes and colorectal cancer susceptibility is still unknown. In this study, we aim to explore whether these variants are correlated with the risk of colorectal cancer in a Chinese population.

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