Open AccessAssociation of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population
Author(s) -
Shijia Wang,
Yue Zhang,
Min Chen,
Yong Wang,
Yifei Feng,
Zhiwu Xu,
Dongsheng Zhang,
Yueming Sun,
Zan Fu
Publication year - 2018
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.24299
Subject(s) - chek2 , chek1 , single nucleotide polymorphism , medicine , colorectal cancer , population , cancer , genetics , oncology , gene , biology , genotype , environmental health , mutation , germline mutation , cell cycle , cell cycle checkpoint
The ATR-CHEK1 and ATM-CHEK2 pathway have been confirmed to be related with the DNA damage response (DDR). Many studies have reported that genetic variants in ATR/CHEK1 and ATM/CHEK2 are associated with cancer risk. However, the association between genetic variants in ATR-CHEK1, ATM-CHEK2 pathway genes and colorectal cancer susceptibility is still unknown. In this study, we aim to explore whether these variants are correlated with the risk of colorectal cancer in a Chinese population.