Open AccessMonoclonal gammopathy of renal significance (MGRS) increases the risk for progression to multiple myeloma: an observational study of 2935 MGUS patients
Author(s) -
Normann Steiner,
Georg Göbel,
Patricia Suchecki,
Wolfgang Prokop,
Hannes Neuwirt,
Eberhard Gunsilius
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.23412
Subject(s) - medicine , monoclonal gammopathy of undetermined significance , multiple myeloma , surgery , gastroenterology , oncology , monoclonal , immunology , monoclonal antibody , antibody
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignancy preceding multiple myeloma (MM) or related disorders. In MGUS, renal impairment caused by deposition of the monoclonal immunoglobulins or free light-chains monoclonal gammopathy of renal significance (MGRS) is often associated with high morbidity and mortality. We analysed the prevalence of renal impairment, clinical features and the long-term outcome in 2935 patients with MGUS.