Open AccessGenome-wide profiling identifies the THYT1 signature as a distinctive feature of widely metastatic Papillary Thyroid Carcinomas
Author(s) -
Greta Gandolfi,
Moira Ragazzi,
Dario de Biase,
Michela Visani,
Eleonora Zanetti,
Federica Torricelli,
Valentina Sancisi,
Mila Gugi,
Gloria Manzotti,
Luca Braglia,
Silvio Cavuto,
Domenico Franco Merlo,
Giovanni Tallini,
Andrea Frasoldati,
Simonetta Piana,
Alessia Ciarrocchi
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.22805
Subject(s) - medicine , thyroid carcinoma , oncology , thyroid
Papillary Thyroid Carcinomas (PTCs) are generally indolent tumors. However, a small but significant percentage of PTCs behaves aggressively, progressing to a diffuse metastatic spreading and leading to patient's death. The lack of reliable markers for predicting the metastatic behavior of these tumors prevents a correct risk based stratification of the disease, thus contributing to the issue of patients' overtreatment. In this study we aimed at identifying genetic features associated with the development of distant metastasis in PTCs.