Open AccessExpression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer
Author(s) -
Soma Samanta,
Shuzo Tamura,
Louis Dubeau,
Paulette MhawechFauceglia,
Yohei Miyagi,
Hiroyuki Kato,
Richard W. Lieberman,
Ronald J. Buckanovich,
Yvonne G. Lin,
Nouri Neamati
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.21569
Subject(s) - medicine , ovarian cancer , tumor progression , protein disulfide isomerase , cancer research , oncology , cancer , protein expression , biology , disulfide bond , gene , genetics , biochemistry
Protein disulfide isomerase (PDI) is an oxidoreductase that is overexpressed in several cancers. PDI family members (PDIs) play a role in various diseases including cancer. Select PDIs were reported as useful markers in other cancers but their expression in ovarian cancer has not been thoroughly assessed. We sought to evaluate the expression of PDI, PDIA6, PDIR, ERp57, ERp72 and AGR3 in ovarian cancer patient samples and examine their prognostic significance.