Open AccessBisphenol A deteriorates egg quality through HDAC7 suppression
Author(s) -
Bin Liu,
Shasha Zhou,
Chenmin Yang,
Ping Chen,
Pingping Chen,
Di Xi,
Hong Zhu,
Yuping Gao
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.21308
Subject(s) - medicine , bisphenol a , benzhydryl compounds , quality (philosophy) , cancer research , pharmacology , endocrinology , chemistry , philosophy , organic chemistry , epistemology , epoxy
Bisphenol A (BPA), a synthetic substance of endocrine disrupter, widely distributes in environment and can affect the health of ovarian follicles, thereby impacting the fertilization ability and pregnancy rate. However, the underlying mechanisms regarding how BPA disrupts the egg quality have not been fully revealed. In this study, we determine that BPA treated female mice display the decreasing HDAC7 expression in ovary and eggs compared to control. Moreover, the global levels of H3K9 and H4K16 acetylation abnormally increase after BPA treatment and recover partially upon HDAC7 compensation. Collectively, our study reveals that BPA deteriorates egg quality through HDAC7 suppression.