Open AccessMechanism of genistein regulating the differentiation of vascular smooth muscle cells into osteoblasts via the OPG/RANKL pathway
Author(s) -
Cheng Shen,
Ye Yuan,
Fuping Li,
Yijie Hu,
Yi Song,
Shulin Zhao,
Qianjin Zhong
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.20167
Subject(s) - rankl , genistein , vascular smooth muscle , microbiology and biotechnology , mechanism (biology) , osteoblast , medicine , signal transduction , cancer research , osteoprotegerin , endocrinology , chemistry , smooth muscle , biology , receptor , biochemistry , activator (genetics) , in vitro , philosophy , epistemology
The present study aimed to investigate the mechanism of genistein, a tyrosine kinase inhibitor, regulating the differentiation of vascular smooth muscle cells (VSMCs) into osteoblasts via the OPG/RANKL (Osteoprotegerin/Receptor Activator of Nuclear Factor-κB Ligand) pathway.