Mechanism of genistein regulating the differentiation of vascular smooth muscle cells into osteoblasts via the OPG/RANKL pathway | Zendy

Cheng Shen | Zendy; Ye Yuan | Zendy; Fuping Li | Zendy; Yijie Hu | Zendy; Yi Song | Zendy; Shulin Zhao | Zendy; Qianjin Zhong | Zendy

Open Access

Mechanism of genistein regulating the differentiation of vascular smooth muscle cells into osteoblasts via the OPG/RANKL pathway

Author(s) -

Cheng Shen,

Ye Yuan,

Fuping Li,

Yijie Hu,

Yi Song,

Shulin Zhao,

Qianjin Zhong

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.20167

Subject(s) - rankl , genistein , vascular smooth muscle , microbiology and biotechnology , mechanism (biology) , osteoblast , medicine , signal transduction , cancer research , osteoprotegerin , endocrinology , chemistry , smooth muscle , biology , receptor , biochemistry , activator (genetics) , in vitro , philosophy , epistemology

The present study aimed to investigate the mechanism of genistein, a tyrosine kinase inhibitor, regulating the differentiation of vascular smooth muscle cells (VSMCs) into osteoblasts via the OPG/RANKL (Osteoprotegerin/Receptor Activator of Nuclear Factor-κB Ligand) pathway.

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