Toll-like receptor expression in human non-small cell lung carcinoma: potential prognostic indicators of disease | Zendy

Alison K. Bauer | Zendy; Brad L. Upham | Zendy; Elizabeth A. Rondini | Zendy; Meredith A. Tennis | Zendy; Kalpana Velmuragan | Zendy; David Wiese | Zendy

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Toll-like receptor expression in human non-small cell lung carcinoma: potential prognostic indicators of disease

Author(s) -

Alison K. Bauer,

Brad L. Upham,

Elizabeth A. Rondini,

Meredith A. Tennis,

Kalpana Velmuragan,

David Wiese

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.19463

Subject(s) - lung cancer , immunostaining , medicine , adenocarcinoma , toll like receptor , innate immune system , receptor , cancer research , carcinoma , cancer , oncology , immune system , lung , immunohistochemistry , pathology , immunology

Lung cancer remains the highest cause of cancer mortality worldwide. Toll-like receptors (TLR) are innate immune receptors that have both pro- and anti-tumorigenic properties. Based on findings from epidemiological studies and in rodents, we hypothesized that elevated TLR expression would be a positive prognostic indicator of disease in non-small cell lung carcinoma patients.

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