Open AccessToll-like receptor expression in human non-small cell lung carcinoma: potential prognostic indicators of disease
Author(s) -
Alison K. Bauer,
Brad L. Upham,
Elizabeth A. Rondini,
Meredith A. Tennis,
Kalpana Velmuragan,
David Wiese
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.19463
Subject(s) - lung cancer , immunostaining , medicine , adenocarcinoma , toll like receptor , innate immune system , receptor , cancer research , carcinoma , cancer , oncology , immune system , lung , immunohistochemistry , pathology , immunology
Lung cancer remains the highest cause of cancer mortality worldwide. Toll-like receptors (TLR) are innate immune receptors that have both pro- and anti-tumorigenic properties. Based on findings from epidemiological studies and in rodents, we hypothesized that elevated TLR expression would be a positive prognostic indicator of disease in non-small cell lung carcinoma patients.