Open AccessLow-dose photon irradiation induces invasiveness through the SDF-1α/CXCR4 pathway in malignant mesothelioma cells
Author(s) -
Yoshikane Yamauchi,
Seyer Safi,
Lena Orschiedt,
Adriane Gardyan,
Stephan Brons,
Juliane Rieber,
Nils H. Nicolay,
Peter E. Huber,
Martin Eichhorn,
Hendrik Dienemann,
Felix J.F. Herth,
Klaus-Josef Weber,
Jürgen Debus,
Hans Hoffmann,
Stefan Rieken
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.19134
Subject(s) - mesothelioma , cancer research , medicine , cxcr4 , irradiation , pathology , receptor , physics , chemokine , nuclear physics
Low-dose photon irradiation has repeatedly been suspected to increase a risk of promoting local recurrence of disease or even systemic dissemination. The purpose of this study was to investigate the motility of malignant pleural mesothelioma (MPM) cell lines after low-doses of photon irradiation and to elucidate the mechanism of the detected phenotype.