Open AccessmiR-217 inhibits laryngeal cancer metastasis by repressing AEG-1 and PD-L1 expression
Author(s) -
Susheng Miao,
Xionghui Mao,
Zhao Song,
Keguan Song,
Xiang Cheng,
Yuanjing Lv,
Huanyv Jiang,
Lei Wang,
Baojun Li,
Xianguang Yang,
Zhennan Yuan,
Xiangdong Cheng,
Hongxue Meng,
Ji Sun
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.19121
Subject(s) - metastasis , medicine , cancer research , cancer , microrna , laryngeal neoplasm , oncology , biology , gene , genetics
High incidences of laryngeal cancer have been reported recently. Increasing our understanding of the molecular mechanisms underlying this malignancy could reveal more effective approaches to treating laryngeal cancer patients and so improve their prognoses. In this study, we explored the biological effects of miR-217 on laryngeal cancer. miR-217 potently inhibited multiple metastatic traits, including cell migration, invasion, proliferation, apoptosis, and EMT, as well as angiogensis. These effects were achieved through downregulation of the miR-217 target gene, AEG-1 and PD-L1. Clinical expression and animal model studies further confirmed our results. These findings provide new insight into the physiological effects of miR-217 in laryngeal cancer and its potential therapeutic use.