Open AccessCuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy
Author(s) -
Leilei Xia,
Ye Wang,
Chen Ya,
Jiuqiong Yan,
Hua-Ying Fan,
Xiaoling Su,
Caihong Zhang,
Man Xu
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.17854
Subject(s) - autophagy , medicine , cisplatin , pi3k/akt/mtor pathway , in vivo , cancer research , cervical cancer , in vitro , cancer , cytotoxicity , chemotherapy , cell growth , apoptosis , chemistry , biology , biochemistry , microbiology and biotechnology
Cervical carcinoma is one of the main causes of women's cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could inhibit the proliferation of cancer cells in vitro and in vivo . Especially CONPs could inhibit tumor growth as cisplatin without weight loss. CONPs could also induce autophagy through AKT/mTOR pathway, which demonstrates that CONPs has the potential clinical applications.