Open AccessHigh expression of FUT3 is linked to poor prognosis in clear cell renal cell carcinoma
Author(s) -
Meng Li,
Liang Xu,
Yuanfeng Yang,
Lin Zhou,
Yuan Chang,
Tiantian Shi,
Cheng Ling Tan,
Huimin An,
Yu Zhu,
Jiejie Xu
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.17717
Subject(s) - fucosyltransferase , medicine , clear cell renal cell carcinoma , nomogram , renal cell carcinoma , oncology , fucosylation , lymphovascular invasion , cancer research , cancer , biology , microbiology and biotechnology , gene , metastasis , biochemistry , glycoprotein , glycan
Some of the fucosylation catalyzed by fucosyltransferase-III mediates the epithelial-mesenchymal transition and enhances tumor cell-macrophage signaling, which promotes malignant transforming and immune evasion. The aim of the study was to investigate the association between the expression of fucosyltransferase-III and clinical outcomes of patients with clear-cell renal cell carcinoma after surgery.