Open AccessExploratory investigation of PSCA-protein expression in primary breast cancer patients reveals a link to HER2/neu overexpression
Author(s) -
Theresa Link,
Friederike Kuithan,
Armin Ehninger,
Jan Dominik Kuhlmann,
Michael Kramer,
A. Werner,
A. Gatzweiler,
Barbara Richter,
Gerhard Ehninger,
Gustavo Baretton,
Michael Bachmann,
Pauline Wimberger,
Katrin Friedrich
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.17523
Subject(s) - medicine , breast cancer , immunohistochemistry , tissue microarray , oncology , prostate cancer , trastuzumab , cancer , biomarker , cancer research , population , triple negative breast cancer , pancreatic cancer , biology , biochemistry , environmental health
Prostate stem cell antigen (PSCA) has been suggested as biomarker and therapeutic target for prostate cancer. Recent advances showed that PSCA is up-regulated in other cancer entities, such as bladder or pancreatic cancer. However, the clinical relevance of PSCA-expression in breast cancer patients has not yet been established and is therefore addressed by the current study.