Open AccessDDX11-AS1 as potential therapy targets for human hepatocellular carcinoma
Author(s) -
Min Shi,
Xiaoyu Zhang,
Huan Yu,
Shihao Xiang,
Ling Xu,
Wei Jiang,
Qiong Wu,
Rongrong Jia,
Yugang Wang,
Xueguan Lu
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.17409
Subject(s) - hepatocellular carcinoma , medicine , china , oncology , political science , law
Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, whose incidence and death rates are still rising. Here, we report the identification of long non-coding RNAs (IncRNAs) that associated with HCC progression and metabolism based on the systematically analysis of large scale RNA-seq data from HCC patients. We identified seven lncRNAs with high confidence which were highly related with prognostic of HCC. Of note, three of them had quite different expression patterns between the control samples and the patients, and their critical roles in cancer progression were validated. We proposed that DDX11-AS1 play important role during HCC oncogenesis and may serve as potential therapy target for HCC.