Open AccessMechanism of oxidative stress p38MAPK-SGK1 signaling axis in experimental autoimmune encephalomyelitis (EAE)
Author(s) -
Liang Wang,
Bin Li,
Moyuan Quan,
Li Lin,
Yuan Chen,
Guo-Jun Tan,
Jing Zhang,
Xiaopeng Liu,
Li Guo
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.17057
Subject(s) - experimental autoimmune encephalomyelitis , oxidative stress , multiple sclerosis , pathogenesis , immunology , inflammation , immune system , sgk1 , signal transduction , medicine , biology , glucocorticoid , microbiology and biotechnology , endocrinology
Multiple sclerosis (MS), a complex disease associated with multifocal demyelination of the central nervous system and poorly understood etiology. It has been previously indicated that many factors, including oxidative stress and p38MAPK-SGK1 pathway, contribute to the pathogenesis of MS.