Open AccessSNORD47, a box C/D snoRNA, suppresses tumorigenesis in glioblastoma
Author(s) -
Bin Xu,
Min-Hua Ye,
Shan Lv,
Qixue Wang,
Minxian Wu,
Bing Xiao,
Chunsheng Kang,
Xingen Zhu
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.16693
Subject(s) - glioma , temozolomide , cancer research , carcinogenesis , downregulation and upregulation , small nucleolar rna , medicine , microrna , long non coding rna , cancer , biology , pathology , gene , biochemistry
SNORD47 is a member of the C/D box small nucleolar RNAs, which have been implicated in cancer development. We intended to investigate the therapeutic potential of SNORD47 in glioma. We found that the expression of SNORD47 was downregulated in glioma tissues samples and inversely associated with advanced tumor stage (WHO grade IV). Kaplan-Meier survival analysis revealed that glioma patients with high SNORD47 expression had longer overall survival than those with low SNORD47 expression. SNORD47 suppressed the proliferation of glioma cells and induced G2 phase arrest. In addition, upregulation of SNORD47 suppressed invasion and epithelial-mesenchymal transition in glioma cells, and combination treatment with lenti-SNORD47 could augment the anti-tumor effect of temozolomide. These results showed that SNORD47 acted as a tumor suppressor in glioma, and provided the potential anti-tumor function in glioma treatment.