Open AccessTargeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations
Author(s) -
Ioana Cosgarea,
Selma Ugurel,
Antje Sucker,
Elisabeth Livingstone,
Lisa Zimmer,
Mirjana Ziemer,
Jochen Utikal,
Peter Mohr,
Christiane Pfeiffer,
Claudia Pföhler,
Uwe Hillen,
Susanne Horn,
Dirk Schadendorf,
Klaus Griewank,
Alexander Roesch
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.16542
Subject(s) - venereology , medicine , skin cancer , dermatology , melanoma , cancer , cancer research
Mucosal melanoma represents ~1% of all melanomas, frequently having a poor prognosis due to diagnosis at a late stage of disease. Mucosal melanoma differs from cutaneous melanoma not only in terms of poorer clinical outcome but also on the molecular level having e.g. less BRAF and more frequent KIT mutations than cutaneous melanomas. For the majority of mucosal melanomas oncogenic driver mutations remain unknown.