Open AccessIncreased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer
Author(s) -
Junhao Lin,
Yonghao Zhan,
Yuchen Liu,
Zhicong Chen,
Jianbo Li,
Wěi Li,
Anbang He,
Liqun Zhou,
Hongbin Mei,
Feng Wang,
Weiren Huang
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.15527
Subject(s) - bladder cancer , carcinogenesis , medicine , cancer , cancer research , long non coding rna , oncology , biology , downregulation and upregulation , gene , biochemistry
Bladder cancer is one of the most common urinary cancers worldwide. Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. In this study, we found that a novel lncRNA Zinc finger E-box-binding homeebox1 (ZEB1) antisense RNA (ZEB1-AS1) was overexpressed in bladder cancer tissues compared to paired noncancerous tissues. Moreover, the expression of ZEB1-AS1 was positive correlated with higher histological grade and TNM stage in bladder cancer. Furthermore, Loss-of-function experiments showed that down-regulation of ZEB1-AS1 not only can suppress cell growth but also can inhibit migration and induce apoptosis in bladder cancer cell lines 5637 and SW780. In conclusion, these findings indicated that ZEB1-AS1 plays regulatory roles in bladder cancer and it may become a novel molecular biomarker of prognosis and therapy in bladder cancer.