Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer | Zendy

Junhao Lin | Zendy; Yonghao Zhan | Zendy; Yuchen Liu | Zendy; Zhicong Chen | Zendy; Jianbo Liang | Zendy; Wu Li | Zendy; Anbang He | Zendy; Liqun Zhou | Zendy; Hongbin Mei | Zendy; Feng Wang | Zendy; Weiren Huang | Zendy

Open Access

Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer

Author(s) -

Junhao Lin,

Yonghao Zhan,

Yuchen Liu,

Zhicong Chen,

Jianbo Liang,

Wu Li,

Anbang He,

Liqun Zhou,

Hongbin Mei,

Feng Wang,

Weiren Huang

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.15527

Subject(s) - bladder cancer , carcinogenesis , medicine , cancer , cancer research , long non coding rna , oncology , biology , downregulation and upregulation , gene , biochemistry

Bladder cancer is one of the most common urinary cancers worldwide. Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. In this study, we found that a novel lncRNA Zinc finger E-box-binding homeebox1 (ZEB1) antisense RNA (ZEB1-AS1) was overexpressed in bladder cancer tissues compared to paired noncancerous tissues. Moreover, the expression of ZEB1-AS1 was positive correlated with higher histological grade and TNM stage in bladder cancer. Furthermore, Loss-of-function experiments showed that down-regulation of ZEB1-AS1 not only can suppress cell growth but also can inhibit migration and induce apoptosis in bladder cancer cell lines 5637 and SW780. In conclusion, these findings indicated that ZEB1-AS1 plays regulatory roles in bladder cancer and it may become a novel molecular biomarker of prognosis and therapy in bladder cancer.

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