Open AccessLong non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma
Author(s) -
Rui Dong,
Xiangqi Liu,
Bin-Bin Zhang,
Bai-Hui Liu,
Shan Zheng,
Ke Dong
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.14992
Subject(s) - hepatoblastoma , angiogenesis , cancer research , gene knockdown , pi3k/akt/mtor pathway , medicine , cell growth , protein kinase b , metastasis , long non coding rna , biology , oncology , cell culture , cancer , apoptosis , rna , genetics , gene
Long non-coding RNAs (lncRNAs) are involved in many biological processes, such as angiogenesis, invasion, cell proliferation, and apoptosis. They have emerged as key players in the pathology of several tumors, including hepatoblastoma. In this study, we elucidate the biological and clinical significance of CRNDE up-regulation in hepatoblastoma. CRNDE is significantly up-regulated in human hepatoblastoma specimens and metastatic hepatoblastoma cell lines. CRNDE knockdown reduces tumor growth and tumor angiogenesis in vivo, and decreases hepatoblastoma cell viability, proliferation, and angiogenic effect in vitro. Mechanistic studies show that CRNDE knockdown plays its anti-proliferation and anti-angiogenesis role via regulating mammalian target of rapamycin (mTOR) signaling. Taken together, this study reveals a crucial role of CRNDE in the pathology of hepatoblastoma. CRNDE may serve as a promising diagnostic marker and therapeutic target for hepatoblastoma.