Open AccessTransforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling
Author(s) -
Xiaodong Zhang,
Qing Fan,
Yan Li,
Zhaoguo Yang,
Liang Yang,
ZhiHong Zong,
Biao Wang,
Xin Meng,
Qin Li,
Jingang Liu,
Hangyu Li
Publication year - 2017
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.14523
Subject(s) - hepatocellular carcinoma , hippo signaling pathway , cancer research , transforming growth factor beta , medicine , yap1 , signal transduction , cell growth , transforming growth factor , oncology , biology , microbiology and biotechnology , transcription factor , gene , genetics
In this study, we examined the expression of core proteins of the Hippo signaling pathway in hepatocellular carcinoma (HCC) cells treated with transforming growth factor-β 1(TGF-β1) and investigated the relationship between TGF-β1 and the Hippo signaling pathway, in order to better understand their roles in HCC and their potential implications for cancer therapy. We prove that the Hippo signaling pathway is involved in the TGF-β1-induced inhibition of the growth of HCC cells. Large tumor suppressor expression (LATS1) was overexpression and yes association protein 1(YAP1) translocated from the nucleus to the cytoplasm in HCC cells treated with TGF-β1. Overexpression of LATS1 and the nucleocytoplasmic translocation of YAP1 play an anti-oncogenetic role in the occurrence and development of liver cancer. Our findings provide new insight into strategies for liver cancer therapy.